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John Mayers signature Fender Stratocaster model.

The Fender Vibrolux is one of John Mayers most common choices.
Guitars
| Guitar | Model | Color | Price |
| Fender | John Mayer Signature Stratocaster | Tobacco Burst | N/A |
| Jackson Custom Shop | Limited Edition 30th Anniversary Soloist | Shocking Pink | N/A |
| Gibson | L-5 CES | Natural | $11,000 |
| Martin | OMJM John Mayer Signature Acoustic | Natural | $3650 |
Amplifiers
| Amplifier | Qty. | Price |
| Fender '65 Super Reverb | 1 | $1550 |
| Fender Custom Vibrolux Reverb | 1 | $1200 |
| Soldano SLO100 Super Lead Overdrive Head | 1 | $4500 |
| Alessandro 2x12 Cabinet | 1 | $2000 |
Pedals & Effects
| FX Unit | Purpose | Price |
| Keeley Katana Clean Boost | Gain boost | $200 |
| Klon Centaur Professional Overdrive | Overdrive | N/A |
| Ibanez TS10 Tube Screamer Classic | Gain boost | N/A |
| Way Huge Aqua-Puss Analog Delay | Delay effect | $150 |
Accessories
| Item | Purpose | Price |
| Boss TU-3 | Tuner | $100 |
| Pedaltrain PT-Pro | Pedalboard | $165 |
| Neumann KMS 105 Microphone | Amplifier | $700 |
| Ernie Ball Regular Slinky .010 - .046 Strings | Electric guitar | $4 |
| Ernie Ball Everlast Extra Light .010 - .050 Strings | Acoustic guitar | $10 |
The Fender Cabronita is used by John Mayer for the performing of Perfectly Lonely .